On April 30, 2021, the United States Environmental Protection Agency’s enforcement office issued a memorandum titled “Strengthening Enforcement in Communities with Environmental Justice Concerns.” In light of the Biden administration’s recent focus on environmental justice and other social responsibility initiatives within environmental regulation, there is heightened scrutiny around compliance with environmental requirements; therefore, supermarkets, box stores, and other commercial businesses administering COVID-19 vaccines should consider the reputational risk of improper handling and disposal of medical wastes.